Orchestration of pulmonary T cell immunity during Mycobacterium tuberculosis infection: Immunity interruptus

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

CD4+ T cells mediate protection against Mycobacterium tuberculosis (Mtb); however, the phenotype of protective T cells is undefined, thereby confounding vaccination efforts. IL-27 is highly expressed during human tuberculosis (TB), and absence of IL-27R (Il27ra) specifically on T cells results in increased protection. IL-27R deficiency during chronic Mtb infection does not impact antigen-specif...

Specific Tuberculosis Immunity During Infection *

The variegated picture of tuiberculous infection, both spontaneous in man and experimentally induced in animals, has puzzled students and led to most complicated explanations. Most of the earlier experimental studies were handicapped by the lack of two fundamentals which now appear so essential to a solution. One of these was the primary lack of information on the tubercle bacillus and its viru...

Infection Mycobacterium tuberculosis for Protective Immunity during Pulmonary The LFA-1 Adhesion Molecule Is Required

Immunity to Mycobacterium tuberculosis

1Department of Infectious Diseases and Immunology, University of Sydney, Sydney, NSW 2000, Australia 2 Infectiologie Animale et Santé Publique, INRA Centre de Tours, Nouzilly 37380, France 3Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 4Centenary Institute of Cancer Medicine and Cell Biology, Newto...

Innate immunity to Mycobacterium tuberculosis.

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance between the bacillus and host defense mechanisms. Traditionally, protective immunity to tuberculosis has been ascribed to T-cell-mediated immunity, with CD4(+) T cells playing a crucial role. Recent immunological and genetic studies support the long-standing notion that innate immunity is also relevant...